Vycellix Platform: VY-OZ
Enabling Superior Cell Transduction & Increasing CRISPR-mediated Gene-editing Rates
VY-OZ is a small molecule which confers significant cell manufacturing benefits as an ex vivo reagent to enhance gene transduction into cytotoxic lymphocytes and hematopoietic stem cells using viral vectors with reproducible and consistent results. VY-OZ is readily adaptable into multiple protocols and is highly differentiated from other genetic modification platforms in its ability to transiently downregulate intracellular anti-viral defense mechanisms, thus enabling desired genes to be more readily integrated to target cells. VY-OZ also significantly improves gene editing rates for CRISPR-based systems.